Total Syntheses of the Actin-Binding Macrolides Latrunculin A, B, C, M, S and 16-epi-Latrunculin B
نویسندگان
چکیده
منابع مشابه
Actin-latrunculin A structure and function. Differential modulation of actin-binding protein function by latrunculin A.
Latrunculin A is used extensively as an agent to sequester monomeric actin in living cells. We hypothesize that additional activities of latrunculin A may be important for its biological activity. Our data are consistent with the formation of a 1:1 stoichiometric complex with an equilibrium dissociation constant of 0.2 to 0.4 micrometer and provide no evidence that the actin-latrunculin A compl...
متن کاملEffect of latrunculin-B on outflow facility in monkeys.
Latrunculin-B (LAT-B), a macrolide derived from the marine sponge Latrunculia magnifica, sequesters monomeric G-actin, leading to the disassembly of actin filaments in cultured cells. In this study, we determined the effect of LAT-B on outflow facility in living monkeys. Total outflow facility was measured by 2-level constant pressure perfusion of the anterior chamber (AC) before and immediatel...
متن کاملLatrunculin B-induced plant dwarfism: Plant cell elongation is F-actin-dependent.
Marine macrolides latrunculins are highly specific toxins which effectively depolymerize actin filaments (generally F-actin) in all eukaryotic cells. We show that latrunculin B is effective on diverse cell types in higher plants and describe the use of this drug in probing F-actin-dependent growth and in plant development-related processes. In contrast to other eukaryotic organisms, cell divisi...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
Total syntheses of amythiamicins A, B and C.
Total syntheses of the thiopeptide antibiotics amythiamicins A, B and C are reported.
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ژورنال
عنوان ژورنال: Chemistry - A European Journal
سال: 2006
ISSN: 0947-6539
DOI: 10.1002/chem.200601135